¡PROGRAM¡


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@Sat, August 26th
Afternoon Registration desk for the guests at the hotel (Atrium)
@Sun, August 27th
13:00- Registration (Atrium)
15:20-15:30 (Main Room) Opening address Yasuo Suzuki
15:30-18:00 (Main Room) Plenary lectures
PL-1 15:30-16:20 Carbohydrate-Carbohydrate Interaction in Basic Cell Biology
Sen-itiroh Hakomori, USA
Chairman: Yoshio Hirabayashi, Japan
PL-2 16:20-17:10 H1 Haemagglutinin Receptor Binding
*John Skehel, Rupert Russell and Steve Gamblin, UK
Chairman: Yasuo Suzuki, Japan
@ 17:10-17:30 Coffee Break
PL-3 17:30-18:20 Synthesis of Tamiflu through New Asymmetric Catalysis
Masakatsu Shibasaki, Japan
Chairman: Makoto Kiso, Japan
18:20-18:45 (Main Room) Special Lecture
SL My Study on Sialic Acids
Tamio Yamakawa, Japan
Chairman: Akemi Suzuki, Japan
19:00-21:00@Reception (Banquet Room)
21:00-22:30@Bar (Bar Lounge)
@Mon, August 28th
7:30-8:30@Breakfast (Dining Room)
8:45-11:51@Session 1: Viral and Bacterial Infection (Main Room)
@Discussion leaders: Harold J. Jennings, Canada; Yasuo Suzuki, Japan
KNL-1-1 8:45-9:10 Going for Baroque: the Mechanisms of Polysialic Acid O-Acetylation and de-O-Esterification of Monomeric Sialic Acid in Escherichia coli K1
*Eric R. Vimr, Susan M. Steenbergen, and Michael R. King, USA
IL-1-1 9:10-9:35 Glycan Microarray Analysis of Human and Avian Influenza Virus Receptor Specificity
James Stevens, Ola Blixt, *James C. Paulson, and Ian A. Wilson, USA
KNL-1-2 9:35-10:00 Structural Studies on Sialidases from Streptococcus pneumoniae and Clostridium perfringens
*Garry Taylor, Guogang Xu, Simon Newstead, Jane Potter, Helen Connaris, Rupert Russell, and Peter Andrew, UK
IL-1-2 10:00-10:15 Highly Pathogenic Avian Influenza Virus and Importance of Its Receptor Binding Surveillance
Yasuo Suzuki, Japan
10:15-10:30 Coffee Break (15 min)
IL-1-3 10:30-10:45 Structural Investigation of the Carbohydrate-Binding Domain VP8*, Critical to Rotavirus Host-Cell Recognition: Strains CRW-8, RRV and Wa That Infect Pig, Monkey and Human
H. Blanchard*, X. Yu., M.J. Kraschnefski, S.A. Scott, and M. von Itzstein, Australia
OP-1-1 10:45-10:56 Sialidase Activity of Influenza A Virus in an Endocytic Pathway Enhances Viral Replication
Takashi Suzuki, Japan
OP-1-2 10:56-11:07 Coliphage Derived Sialidase Preferentially Recognizes Non-Reducing End of Polysialic Acid
*Katsuhide Miyake, Yohei Kataoka, and Shinji Iijima, Japan
OP-1-3 11:07-11:18 The Prodigious Catalytic Activity of the Sialidase from Micromonospora viridifaciens
A.J. Bennet*, J.N. Watson, A.A. Narine, and C. Chen, Canada
OP-1-4 11:18-11:29 Ab Initio Molecular Orbital Study of Influenza A Virus Hemagglutinin-Sialosaccharide Interaction
Toshihiko Sawada, Japan
OP-1-5 11:29-11:40 Structural Basis for the Inhibition of Human Cytosolic Sialidase Neu2 by Influenza Virus Drugs
Chavas L.M.G., Kato R.*, Mann M.C., Thomson R.J., Dyason J.C., von Itzstein M., McKimm-Breschkin J., Colman P.M., Fusi P., Venerando B., Tettamanti G., Monti E., and Wakatsuki S., Japan
OP-1-6 11:40-11:51 Siglec-9 Inhibits Innate Immunity
*Ken-ichi Nishijima, Munetoshi Ando, Takeshi Hashimoto, and Shinji Iijima, Japan
12:00-12:45 Lunch (Dining Room)
12:45-13:45 Luncheon Seminar Provided by Wako Chemicals (Main Room)
14:00-16:00@Session 2: Sialidases and their Biological Role (Main Room)
@Discussion leaders: Roland Schauer, Germany; Guido Tettamanti, Italy
IL-2-1 14:00-14:20 Identification and Characterization of Sialidases from Zebrafish (Danio rerio)
Marta Manzoni, Paolo Colombi, Luana Rubaga, Nadia Papini, Natascia Tiso, Bruno Venerando, Guido Tettamanti, Roberto Bresciani, Augusto Preti, Francesco Argenton, Giuseppe Borsani and *Eugenio Monti, Italy
IL-2-2 14:20-14:38 Predicted Molecular Interaction between Human Lysosomal Sialidase (Neuraminidase 1) and Protective Protein/Cathepsin A
*Kohji Itoh, Yoshito Kadota, Seiichi Aikawa, Fumiko Matsuzawa, Kohji Tsuta, Hitoshi Sakuraba, Tadashi Satoh, and Soichi Wakatsuki, Japan
IL-2-3 14:38-14:58 Lysosomal Sialidase Neu4: a Novel Role in Glycolipid Catabolism
*Pshezhetsky A.V., Seyrantepe V., Morales C.R., and Levade T., Canada
IL-2-4 14:58-15:18 Spreading the neus: the Role of Sialic Acid Modulation in Neutrophil Function
*Alan S. Cross, Simeon E. Goldblum, and Nicholas M. Stamatos, USA
IL-2-5 15:18-15:35 Regulatory Roles of Plasma Membrane-Associated Sialidase (NEU3) in Expression of Malignant Properties of Human Cancer
*Taeko Miyagi, Tadashi Wada, Keiko Hata, Kazunori Yamaguchi, Kengo Kato, Seiji Ueno, and Setsuko Moriya, Japan
KNL-2 15:35-16:00 Induction of Axonal Differentiation by Silencing Plasma Membrane Associated Sialidase Neu3 in Neuroblastoma Cells
Rea Valaperta, Manuela Valsecchi, Federica Rocchetta, Massimo Aureli, Simona Prioni, Alessandro Prinetti, Vanna Chigorno, and *Sandro Sonnino, Italy
16:00-16:30 Coffee Break (Lobby)
16:30-18:30@Session 3: Chemical and Physical Approach (Main Room)
@Discussion leaders: Yukishige Ito, Japan; Yasuhiro Kajihara, Japan
IL-3-1 16:30-16:45 Synthetic Study on the Complex Glycans Containing Sialic Acid Congeners
*Hiromune Ando, Japan
IL-3-2 16:45-17:00 Efficient Synthesis of Sialoglycosides Using New Synthetic Methodologies
*Koichi Fukase, Katsunori Tanaka, Shin-ichi Tanaka, Hiroomi Tokimoto, Yasutaka Mori, Chika Kasamatsu, Yumiko Hori, and Takashi Goi, Japan
IL-3-3 17:00 -17:15 Stereoselective Synthesis of Oligo-ƒ¿(2,8) and ƒ¿(2,9) Sialic Acids
*Hiroshi Tanaka, Yuji Nishiura, and Takashi Takahashi, Japan
OP-3-1 17:15-17:30 Chemical Basis for the Formation of a Unique Sialylate Linkage Utilizing CMP-Neu5Ac During Sialyltransferase Reaction
*Y. Kajihara, S. Nishigaki, M. Sugahara, K. Hirano, N. Yamamoto, T.Sakakibara, S. Koizumi, and M. Miyano, Japan
OP-3-2 17:30-17:45 A Transglycosylation Reaction of Sialooligosaccharide to Cyclohexanol Derivative by Using Endo-M
Yusuke Tomabechi, Yuki Odate, Ryuko Izumi, and *Toshiyuki Inazu, Japan
IL-3-4 17:45-18:00 Synergism in Sialylation: Reasons and Consequences
*Leonid O. Kononov, Nelly N. Malysheva, and Elena G. Kononova, Russia
KNL-3 18:00-18:30 Design of New Glycosyltransferase Inhibitors
*Richard R. Schmidt, Germany
18:30-19:30 Dinner (Dining Room)
18:30-19:30 International Organizing Committee Meeting (??)
19:30-22:00 Poster session (Lobby)
20:00-22:30 Bar (Bar Lounge)
@Tue, August 29th
7:30- 8:30 Breakfast (Dining Room)
8:45-11:45@Session 4: Medicinal and Industrial Applications (Main Room)
@Discussion leaders: James C. Paulson, USA; Nicolai Bovin, Russia; Makoto Kiso, Japan
KNL-4-1 8:45-9:10 Pandemic Influenza \The Re-emergence of an Old Threat
Mark von Itzstein, Australia
KNL-4-2 9:10-9:35 Carbohydrate Microarrays and Studies of the Interplay of Sialyl and Sulfo Motifs in Recognition by Selectins and Siglecs
*Ten Feizi, UK
IL-4-1 9:35-9:55 Design of a Probe for Neuraminidase to Capture and Identify Influenza Viruses
@ Shih-Hsiung Wu, Taiwan
IL-4-2 9:55-10:15 Field Diagnostics of Avian Influenza: Fast and Simple
*N. Bovin, O. Kiselev, L. Mochalova, I. Lubavina, and A. Tuzikov, Russia
10:15-10:30 Coffee Break
IL-4-3 10:30-10:50 Synthetic Glycopeptide Library for Investigating Molecular Functions and Essential Structures of Tumor-Associated Antigenic Glycoprotein
*Shin-Ichiro Nishimura, Naoki Ohyabu, Takahiko Matsushita, Hiroshi Hinou, Ryuko Izumi, Hiroki Shimizu, and Hirosato Kondo, Japan
IL-4-4 10:50-11:05 Designed Sugars against Influenza and Mycoplasma-Related Diseases
*Yoshihiro Nishida, Yuko Shingu, Seiji Sato, and Kazuhiro Matsuda, Japan
OP-4-1 11:05-11:15 Towards the Design of Human Sialidase 3 (NEU3) Selective Inhibitors: Homology Modeling and Preliminary Docking Studies
*Sadagopan Magesh, Tohru Suzuki, Taeko Miyagi, Hideharu Ishida and Makoto Kiso, Japan
OP-4-2 11:15-11:25 Sialic Acids: Unique Component Characters That Enhance Dramatically the Performance of Glycocodes
Kenichi Kasai, Japan
OP-4-3 11:25-11:35 The Effect of N-acyl Sialic Acid Precursor Treatment on Polysialic Acid Expression by Neuronal Cells
Rob A. Pon, Nancy J. Biggs and *Harold J. Jennings, Canada
OP-4-4 11:35-11:45 Sialic Acid: a Novel Nutrient That Enhances Learning and Memory
*Bing Wang, Bing Yu, Muhsin Karim, Honghua Hu, Paul McGreevy, Peter Petocz, Suzanne Held, and Jennie Brand-Miller, Australia
12:30-18:00 Lunch and Excursion (Bus tour)
19:00-22:30 Banquet (Banquet Room)
@Wed, August 30th
7:30-8:30 Breakfast (Dining Room)
8:45-11:50@Session 5: Sialic acid metabolism and unusual sialylation (Main Room)
@Discussion leaders: Yuan C. Lee, USA; Frederic A. Troy, USA
KNL-5-1 8:45-9:10 Phenotypic Characteristics of Mice Expressing Variant Allelic Combinations of the Polysialyltransferase genes St8siaII and St8siaIV
*Rita Gerardy-Schahn, Hildegard Geyer, Birgit Weinhold, Sebastian P. Galuska, Imke Oltmann-Norden, Rudolf Geyer, Iris Ršckle, Herbert Hildebrandt, and Martina M&#252hlenhoff, Germany
KNL-5-2 9:10-9:35 Basis for the Protein-Specificity of Polysialic Acid Addition to NCAM
*Karen J. Colley, Brett E. Close, Kristin Geiger, and Shalu Shiv Mendiratta, USA
IL-5-1 9:35-9:55 Sialyl-Tn Expression Enhances Tumorigenecity Of Breast Cancer Cells
Sylvain Julien, Anne Harduin-Lepers, Marie-Ange Krzewinski-Recchi, Eric Adriaenssens, Anne-Sophie Vercoutter-Edouart, Franz-Georg Hanisch, Xuefen Le Bourhis, and *Philippe Delannoy, France
IL-5-2 9:55-10:15 Biological importance of the biochemical modification of the N-acetyl side chain of sialic acid
Werner Reutter, Germany
10:15-10:30 Coffee break
IL-5-3 10:30-10:50 Polysialic Acid on Microglia Cell and Its Clearance After LPS-Induced Activation
*Chihiro Sato, Uichiro Yabe, Makoto Sawada, and Ken Kitajima, Japan
IL-5-4 10:50-11:10 The Rainbow Trout CMP-KDN Synthetase Utilizes an Alternative Nuclear Localization Signal to That Identified in the Mouse Enzyme
*Joe Tiralongo, Akiko Fujita, Chihiro Sato, Ken Kitajima, Rita Gerardy-Schahn, and Anja K. Muenster-Kuehnel, Australia
IL-5-5 11:10-11:30 KDN and Polysialic Acids: Reflections on the Road We Have Come Along and Future Directions
Sadako Inoue, Japan
OP-5-1 11:30-11:40 A GNE Knockout Mouse Expressing Human V572L Mutation Develops Features Similar to Nonaka Myopathy or Distal Myopathy with Rimmed Vacuoles (DMRV)
*May Christine V. Malicdan, Satoru Noguchi, Yukiko Hayashi, Ikuya Nonaka, and Ichizo Nishino, Japan
12:00-12:45 Lunch (Dining Room)
12:45-13:45 Luncheon Seminar Provided by Shimadzu (Main Room)
14:00-16:00@Session 6: Sialic Acid and Disease (Main Room)
@Discussion leaders: Reiji Kannagi, Japan; Werner Reutter, Germany
KNL-6 14:00-14:25 Possible Presence of a Detoxification Mechanism in Tay-Sachs Disease by Taurine-Conjugation of the Sialic Acid Residue in GM2 Ganglioside
*Yu-Teh Li, and Su-Chen Li, USA
IL-6-1 14:25-14:50 The Polysialic Acid Glycotope: Degree of Polymerization and Glycopathology
Daisuke Nakata, Kyoung-Ho Park, Bum Jung Park, Paul J. Donald, and *Frederic A. Troy II, USA
IL-6-2 Canceled
IL-6-3 14:50-15:15 Campylobacter Sialyltransferase Gene Polymorphisms Define Guillain-Barre or Fisher syndrome
Nobuhiro Yuki, Japan
IL-6-4 15:15-15:35 Regulatory Mechanisms for the Malignant Properties of Cancer Cells with Gangliosides
*Koichi Furukawa, Kazunori Hamamura, Yusuke Ohmi, Momoko Tsuji, Hideyuki Nakashima, Keiko Furukawa, Japan
IL-6-5(added) 15:35-15:50 Differential Recognition of O-Acetylated Sialic Acids by Orthomyxo- and Nidoviruses
Juliane Mayr, Thomas Haselhorst , Barbara Zehentner , Wolfgang Huber Cornelia Hauser-Kronberger , Robert Lang , Mark von Itzstein , and Reinhard Vlasak , Austria
OP-6-1(added) 15:50-16:05 Interaction of Siglecs with Synthetic Sialosides and Trypanosoma cruzi
Rahul Ravindran, Fabian Jacobi, Antje Kelm, Nicolai Bovin, Christiane Steeg, Thomas Jacobs, Sorge Kelm, Germany
16:05-16:30 Coffee Break (Lobby)
16:30-18:30@Session 7: New aspects of sialic acid recognition (Main Room)
@Discussion leaders: Akemi Suzuki, Japan; Hiroshi Nakada, Japan
KNL-7-1 16:30-16:55 Sialic Acid Binding Properties of Recombinant and Naturally Expressed Siglecs of the Immune System
Sarah McMillan, Diana Gil, Jiquan Zhang, Helen Attrill, Daan van Aalten, Nicolai Bovin, and *Paul R. Crocker, UK
KNL-7-2 16:55-17:20 Two Modes of Evolution in Sialobiology
Ajit P. Varki, USA
IL-7-1 17:20-17:35 Discovery of Siglecs with Activating Signaling Potential
*Takashi Angata, Japan
IL-7-2 17:35-17:55 Immunoglobulin Isotype-Dependent Regulation of B Cell Antigen Receptor Signaling Mediated by Siglec2/CD22
Motohiko Sato, Chisato Wakabayashi, Yasuhisa Hokazono, Taishi Onodera, Takahiro Adachi, and *Takeshi Tsubata, Japan
IL-7-3 17:55-18:10 Change of Neu5Gc Modification of Sialic Acid in Activated B Cells and Its Biological Significance
Hiromu Takematsu, Japan
IL-7-4 18:10-18:30 Sialic Acid Recognition in the Skin and Gut
Reiji Kannagi, Japan
18:30-18:40@Closing address (Main Room) Makoto Kiso
18:40-19:30@Dinner (Dining Room)
@Thu, August 31st
7:30- 8:30@Breakfast (Dining Room)
9:00-15:00@Optional tour (Bus tour)


¡POSTER PRESENTATION¡
PP-1 Glycomic Mapping and Identification of Sialyl Lex and Sialyl Lea on Mucins from Human Ovarian Cyst Fluid
*Albert M.Wu, Shin-Yi Yu, Zhangung Yang, Kay-Hooi Khoo, and Winifred M. Watkins, Taiwan
PP-2 Glycosylation of Sialic Acid via Chemical Approach
Cheng-Chung Wang, and Shang-Cheng Hung*, Taiwan
PP-3 Synthesis of 9-Formyl Derivatives of Sialic Acid
*K. Furuhata, M. Ando, N. Sato, and Y. Uda, Japan
PP-4 Study on C-2 Substitution through Reduction of C-1 Position of Sialic Acid
*Muneyoshi Kikkawa, and Teruo Yoshino, Japan
PP-5 Effects of R344-Residue Substitutions on Intracellular Processing and Protective Function of Human Lysosomal Protective Protein/Cathepsin A
*Yoshito Kadota, Seiichi Aikawa, Fumiko Matsuzawa, Kohji Tsuta, Hitoshi Sakuraba, and Kohji Itoh, Japan
PP-6 Soluble Expression of Recombinant Human ST6Gal I in Escherichia coli
*Yugo Kanai, Kazuya I.P.J. Hidari, Shotaro Iwamoto, Yasuo Suzuki, and Takashi Suzuki, Japan
PP-7 Trans-Sialidase Activity of Human Serum
*K.L. Dobrochaeva, G.V. Pazynina, and N.V. Bovin, Russia
PP-8 ƒ¿-Selective Sialylation Using Neu5Ac-1-Amide Derivatives
*Ryo Okamoto, Shingo Souma and Yasuhiro Kajihara, Japan
PP-9 Expression of the Murine CMP-Sialic Acid Transport Protein in Pichia pastoris
*Andrea Maggioni, Rita Gerardy-Schahn, Mark von Itzstein, and Joe Tiralongo, Australia
PP-10 Influenza A Virus-Binding Sialoglycoproteins in a Cell Membrane Fraction Extraxted from Human Alveolar Epithelial A549 Cells
*Daisei miyamoto, Makoto Ito, Yuki Okawa, Shogo Sato, Yasuo Suzuki, and Takashi suzuki, Japan
PP-11 Kinetic Analysis of the Binding of Influenza Viruses to Endogenous Gangliosides by SPR
*Shizumi Shimada, Kazuya I.P.J. Hidari, Yasuo Suzuki, and Takashi Suzuki, Japan
PP-12 Measurements of Bovine Milk Powder Ganglioside GD3: Analysis of Seasonal Trends and International Comparisons
*Paul McJarrow, Sonia Patel, Frith Coolbear, and Alastair MacGibbon, New Zealand
PP-13 Germinal Center B Cells Suppress CD22-Ligand Expression by Means of CMP-N-Acetylneuraminic Acid Hydroxylase Downregulation
*Yuko Naito, Hiromu Takematsu, Harumi Yamamoto, Reiko Fujinawa, Manabu Sugai, Yasushi Okuno, Gozoh Tsujimoto, and Yasunori Kozutsumi, Japan
PP-14 Synthetic Study of Sialo-cantaining Oligosaccharide Using N-Troc Sialyl Donors
*Yuji Nishiura, Hiroshi Tanaka, Masaatsu, Adachi, and Takashi, Takahashi, Japan
PP-15 Developmental Change of Neu4 Expression in Mouse Brain and Its Involvement in Neuronal Cell Differentiation
*Kazuhiro Shiozaki, Koichi Koseki, Kazunori Yamaguchi, Momo Shiozaki, and Taeko Miyagi, Japan
PP-16 Flagellasialin, a Novel Polysialic Acid Glycoprotein in Sea Urchin Sperm Is Involved in Sperm Motility
Shinji Miyata, Chihiro Sato, Hironobu Kumita, Masaru Toriyama, Victor D. Vaquier, and *Ken Kitajima, Japan
PP-17 Studies on Acid Instability of O-Glycosides of Cyclic Sialic Acid
*Shoko Iwata, Nobuhiko Kawakami, Chihiro Sato, Hiromune Ando, Makoto Kiso, Reiji Kannagi, and Ken Kitajima, Japan
PP-18 In Vivo Comparison of the Polysialylation Properties of ST8SiaII and ST8SiaIV
*Sebastian Galuska, Rudolf Geyer, Rita Gerardy-Schahn, Martina M&#252hlenhoff, and Hildegard Geyer, Germany
PP-19 Production of Recombinant Glycoprotein with Low Levels of N-Glycoylneuraminic Acid in Chinese Hamster Ovary Cells by Co-Expressing CMP-Sialic Acid Transporter
*Dong Gyung Kang, and Hyung Joon Cha, Korea
PP-20 Systematic Analysis of the Sialidases and Sialidase-Related Genes Using a Phylogenetic Approach
*Seonghun Kim, Doo-Byoung Oh, Oh Suk Kwon, and Hyun Ah Kang, Korea
PP-21 Molecular Mechanism for Controls of Metabolism of Deaminoneuraminic Acid (KDN) in Mammalian Cells
*Shinji Go, Chihiro Sato, and Ken Kitajima, Japan
PP-22 Application of Multi-Dimensional HPLC Mapping Method to N-Glycosylation Profiling in Viral Glycobiology
*Hirokazu Yagi, Naoko Yasukawa, Noriko Takahashi, Chao-Tan Guo, Tadanobu Takahashi, Wakoto Bukawa, Takashi Suzuki, Yasuo Suzuki, and Koichi Kato, Japan
PP-23 CMP-Sialic Acid Synthase of Group B Streptococcus Has Sialic Acid O-Acetylesterase Activity and Reduces O-Acetylation of Sialic Acids on the Capsular Polysaccharide
Amanda L. Lewis, *Silpa Patel, Sandra L. Diaz, Wesley Ryan, Xi Chen, Feng-Ying C. Lin, Victor Nizet, and Ajit Varki, USA
PP-24 Identification of Structural Elements That Determines the Substrate Recognition Toward Neu5Ac and KDN in Vertebrate CMP-Sia Synthetases
Fujita, A., Sato, C., Nakata, D., M&#252nster-K&#252hnel, A. K., Gerardy-Schahn, R., and Kitajima, K., Japan
PP-25 Preparation of a Fluorous Protecting Group and Its Application to the Chemoenzymatic Synthesis of Sialidase Inhibitor
*Kiyoshi Ikeda, Hitomi Mori, Takuma Ishikawa, Wataru Unno, and Masayuki Sato, Japan
PP-26 Synthesis of Useful Ganglioside Probes Designed for Biomedical Application
*Hideharu Ishida, Tatsuya Komori, Takeru Yoshikawa, Akihiro Imamura, and Makoto Kiso, Japan
PP-27 See OP-1-1
PP-28 See OP-1-2
PP-29 See OP-1-3
PP-30 See OP-1-4
PP-31 See OP-1-5
PP-32 See OP-1-6
PP-33 See OP-3-1
PP-34 See OP-3-2
PP-35 See OP-4-1
PP-36 See OP-4-2
PP-37 See OP-4-3
PP-38 See OP-4-4
PP-39 See OP-5-1