Sialobiology and Other Novel Forms of Glycosylation

Edited by Y. Inoue, Y.C.Lee and F.A.Troy II

ISBN4-907773-00-5, 257*210mm, 308pp (including 8 color pages), hard cover, index,
Price: 12,000 JPYen

Among the sugar residues in glycoconjugates, sialic acid is perhaps the only one that is used alone for thematic meetings. Since its discovery in animal cells some 60 years ago, this unique sugar still occupies a prominent position in glycoscience. More than 40 naturally occurring derivatives of the parent sialic acid, neuraminic acid, have now been described. And, as this monograph verifies, there is as much diversity in the areas of sialic acid research as there are in the different sialic acid structures. This monograph summarizes much of the contemporary research in sialobiology, studies that seek to understand the occurrence, structure, synthesis, and function of the different mono- and polysialylated glycotopes that are expressed in species that transcend the evolutionary scale from man to bacteria. Characterization of the different sialic acid binding proteins, including the mono- and polysialyltransferases, sialidases and siglec-like lectins are also at the forefront of studies to elucidate the molecular mechanisms of sialylation, sialidase catalysis and the role that sialic acid binding molecules play in health and disease. The biological significance and therapeutic potential of these proteins and their cognate sialylated structures are already beginning to provide unexpected but useful model systems for evaluating new treatments and chemopreventive drugs.

(from PREFACE)